Best L Tryptophan Supplements 2020 (Buyers Guide + Review )

You’ll want to understand the benefits and safety measures before choosing the best L-Tryptophan supplement. This is important as L-Tryptophan is an amino acid that could change the level of important neurotransmitter in your body.

What Is L-Tryptophan?

Best L Tryptophan Supplements

L-Tryptophan is an essential amino acid needed by the body to regulate our emotional wellness, such as preventing over anxious respond and calming our mind from stress. However, L-Tryptophan is not produced in the body and is only available by consuming protein in plants and meat.

Turkey is one of the commonly cited sources of L-Tryptophan but is often linked to drowsiness that follows. Here are other L-Tryptophan-riched foods where you can derive the essential amino acid.

  • Seeds & Nuts
  • Soy Bean
  • Cheese,
  • Lamb, Beef & Pork
  • Chicken
  • Salmon
  • Oats
  • Eggs

If your regular diet is missing these L-Tryptophan enriching foods, you stand the risk from suffering from anxiety, depression or bouts of insomnia. This is because L-Tryptophan is eventually converted to serotonin, melatonin, and vitamin B6. Serotonin is an important hormone that helps balance your mood while melatonin ensures a regular circadian sleep cycle for you. (1)

How L-Tryptophan Works

You may have realized that our brain is an ultra-complex network of billions of brain cells. These tiny cells are connected by neurotransmitters to transmit messages to each other.  Serotonin is a major neurotransmitter that provides neural-pathway for the tiny brain cells.

The lack of serotonin has been linked to an increased in anxious thoughts and overreaction to stress. When you’re under a distressful situation, your the serotonin level in your brain reduces, and fight-or-flight hormones like adrenaline are produced in excess.

Some people suffer from serotonin deficiency and that results in anxious behavior. As serotonin is one of the components converted from L-Tryptophan, it becomes a common suggestion that taking the L-Tryptophan supplements can help to reduce stress. (2)

This suggestion is not unproven. In fact, a clinical study where 25 participants are given a high intake of L-Tryptophan diets shows a decrease in anxiety and depressive symptoms after four days.

What happens when you take L-Tryptophan is that the amino acid is converted into 5-HTP, an amino acid precursor that is later broken down into serotonin, melatonin and vitamin B6. This is how the necessary hormones are produced for reducing stress and sleep.

Health Benefits Of L-Tryptophan

Here are potential health benefits that are associated with L-Tryptophan.

  • Reduces anxietyStudies have indicated that L-Tryptophan is effective in reducing anxiety when prescribed at a controlled dosage.
  • It Helps With Depression – L-Tryptophan is equally effective in reducing depressive disorders as it is with its equally crippling cousin, anxiety. The increase in serotonin as the L-Tryptophan is broken down proves to be effective in lifting a depression-stricken person’s mood.
  • Reduces Severity Of Migraines – Migraines can ruin the day of a perfectly energetic person. The pulsing one-sided headache has long been linked to the low level of serotonin. Taking L-Tryptophan boosts serotonin level and thus helps reduce the occurrence and severity of migraines.
  • Helps With Sleep Disorders – Besides serotonin, L-Tryptophan is also converted into melatonin. Melatonin is a sleep hormone that is naturally produced when the body senses a dark surrounding. It helps to prepare the body and mind for sleep. Therefore, taking this essential amino acid can help in regulating your circadian cycle.
  • It Promotes Weight Loss – L-Tryptophan is NOT your miracle weight loss pill, but it plays an important role to ensure your body metabolism is at its optimum level. Besides helping your weight loss regime, it also ensures that you experience less fatigue and increased endurance.
  • It alleviates pain: L-Tryptophan is also linked to improving pain tolerance when taken orally.
  • Reduces Pre-Menstrual Dysphoric Disorder: Studies have pointed to the positive effect of L-Tryptophan in reducing PMDD, a debilitating physical and emotional symptoms that affect women severely.

How To Take L-Tryptophan Safely

L-Tryptophan supplements may be one of the most potent remedies for reducing stress, but taking it at an incorrect dosage can cause serious side effects. It is sold as a supplement and not as a drug. As such, there are no standards in determining the dosage although 500 mg is regularly recommended for a regular supplement.

If you’re taking L-Tryptophan to address your stress or other health issues, the following table provided by the University Of Michigan will be helpful.

  • Insomnia: 1-2 grams at bedtime
  • Depression or anxiety: 3-6  grams a day
  • Pre-Menstrual Dysphoric Disorder: 2 to 6 grams per day, during the second half of the menstrual cycle

L-Tryptophan is sometimes taken for addressing other health issues. If you’re in doubt of the right dosage of L-Tryptophan, always consult your doctor for clarifications.

Precautions and Side Effects Of L-Tryptophan

Unlike some supplements, L-Tryptophan can cause serious side effects when taken in an extreme dosage or when taken with certain medications. In 1989, there are cases of individuals developing eosinophilia-myalgia syndrome (EMS) and suggestions that they are linked to L-Tryptophan supplement. (3)

While there is a suspicion that suggests the cases are attributed to contaminated L-Tryptophan products, it results in a massive recall of the amino acid supplements.

Overdosing of L-Tryptophan leads to a condition termed as Serotonin Syndrome. This causes physical symptoms of irritability, fever, sweating, fluctuating blood pressure, and irregular heart rate. Prolonged Serotonin Syndrome can lead to death. Therefore, it is always mandatory to consult your doctor if you’re doubtful of the right dosage. (4)

L-Tryptophan should never be used together with medications for depression and sedative depressants as such combination can result in severe side effects. Individuals who are suffering from kidney or liver problems and eosinophilia should refrain from taking L-Tryptophan. (5)

There is insufficient research to suggest the safety of L-Tryptophan for pregnant and breastfeeding women. It is recommended that expecting women and lactating mums should stop taking L-Tryptophan.

How Long Does It Take For L-Tryptophan To Work

The question of how long L-Tryptophan starts providing relaxing effect does not warrant a straight forward answer. While it may take only 30 minutes for L-Tryptophan to enter your bloodstream, you’ll only benefit from the positive effect when it was converted to 5-HTP and ultimately, serotonin and melatonin.

Assuming that your body doesn’t have any problems in doing that, you should be feeling calmer not long after taking L-Tryptophan.

How To Choose The Right L-Tryptophan

Considering the potency of L-Tryptophan, you wouldn’t want to choose the cheapest supplement that you come across on the shelf. Instead, it pays to evaluate these factors before making a decision.

  • Dosage – The first consideration is the dosage of the L-Tryptophan. While you’ll want the dosage on the safe spectrum, you do not want it to be too weak to bring any benefits. A minimum of 500 mg commonly recommended for a regular supplement.
  • Safety And Purity – Manufacturing and testing are two important elements that determine the purity, potency, and safety of the supplement that you received. Certifications like cGMP, Gluten-Free or third-party tested are bonus points.
  • Manufacturer Reputation – You want to buy your L-Tryptophan supplements from manufacturers that have a proven track record. Thanks to the internet, you’ll get to read reviews on some of the manufacturer’s website, and that will give you a general idea of the quality of the products.

Where Can You Buy L-Tryptophan

While L-Tryptophan is usually sold at local pharmacies, many consumers are turning to online suppliers to get the supplement. You can visit the reputable supplement manufacturers that sell L-Tryptophan on their online store, or try to get better-priced products at Amazon. Besides, you get to compare reviews to determine the best L-Tryptophan product for you.

10 Top Rated L-Tryptophan Supplements 2020

Important: If you’re suffering from any medical conditions, you’re advised to consult your doctor before using this supplement. This article is not written by a medical professional, health expert or a doctor. Thus, it is not a substitute for medical diagnosis or treatment.

Sometimes, finding the right L-Tryptophan on Amazon can take up precious time, as you got to read through the ingredients and browse through the reviews by hundreds of consumers. I’ve spent some time doing the research and compiled this list to help you with your decision.

1. NOW Food L-Tryptophan Capsules

  • L-Tryptophan: 500 mg (1 capsule)
  • Size: 120 Capsules

Best L Tryptophan Supplements

NOW Food celebrates its 50th anniversary in 2018 and is still committed to its original intention of empowering peoples life with natural products. It has remained family-owned and prioritizes on producing affordable organics and safe products while protecting the environment.

This bottle of L-Tryptophan capsules will be handy to help boost your mood. It is manufactured in NOW’s facility that complies with strict quality processes. The capsules are also tested by scientific laboratories to ensure that it is safe and potent for consumption.

The capsules are made of vegetarian-friendly ingredients and are NON-GMO certified. It is recommended that you take 2-3 capsules per day to ease stress. Taking the supplement before bedtime helps to increase melatonin, and promotes better sleep.


  • Pharmaceutical Grade L-Tryptophan
  • Encourage positive mood
  • Non-GMO and Vegetarian Capsules.


  • Some may experience side effects
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2. Source Naturals L-Tryptophan

  • L-Tryptophan: 1500 mg ( 3 capsules)
  • Size: 150 Capsules

Best L Tryptophan Supplements

It was in 1982 when Source Naturals was founded to address the demand for a nutritional enhancing formula that combines herbs, nutrients, and nutraceuticals. Since then, it has developed more than 600 products of high quality that leads to a positive transformation of health.

This is one great L-Tryptophan supplement that helps your body to produce serotonin and melatonin, both important component that regulates emotion and sleep. For the best effect, it is suggested that you take one capsule 3 times a day between meal.

It also helps regulate your sleep cycle if you take the capsules before bedtime. This L-Tryptophan supplement also helps to boost your immune system and promote the health of the nervous system. Regular third party testings ensure that you’ll receive a highly pure L-Tryptophan supplement.


  • High purity ensured.
  • Boost immune system
  • Promote mental health


  • Ineffective for some individuals
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3. Amazing Nutrition L-Tryptophan Dietary Supplement

  • L-Tryptophan: 1000 mg ( 1 capsule)
  • Size: 60 Capsules

Best L Tryptophan Supplements

It is undeniable that living a hectic lifestyle means missing out on the important nutrients in regular meals. Amazing Nutrition aims to correct that by offering top quality health supplements for busy individuals. Each of its products is made from the finest ingredients and with a high level of purity.

A single capsule of Amazing Nutrition’s L-Tryptophan contains 1,000 mg of essential amino acids. It is what you need to start after a long stressful day. A single capsule taken 2-3 times a day will provide the necessary L-Tryptophan to boost the serotonin in your brain.

The capsules are potent and pure, as they are produced in a GMP-certified facility in the US. The capsules are free from harmful additives or fillers. There are also no drugs being used in the process. Therefore, there’s no worry of addiction after taking the L-Tryptophan capsules.


  • Regulates mood for stress relief.
  • Produced in a GMP-certified facility.
  • A strong concentration of L-Tryptophan in capsule


  • Some individuals experience side effects.
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4. Superior Labs Pure L-Tryptophan For Sleep And Relaxation

  • L-Tryptophan: 500 mg ( 1 capsule)
  • Size: 120 Capsules

Best L Tryptophan Supplements

Speedy production is probably not the forte of Superior Labs. But that’s because it takes no shortcut in producing safe and high-quality supplements. It stands by its products and would guarantee that none of its product contains any traces of harmful chemicals.

If you’re a vegetarian and hoping to take L-Tryptophan to reduce your stress, these vegetarian capsules will be ideal for you. Besides that, the capsules are totally free from additives, heavy metals, and fillers that may compromise the purity.

Produced in FDA GMP-certified facilities, these capsules will increase your feel-good hormone when taking one capsule 2-3 times daily after you’ve completed your meal. You can also rely on the L-Tryptophan supplement to lull you to sleep by taking the capsules before bedtime.


  • Vegetarian-friendly capsules
  • Effective in sleep and relaxation
  • Manufactured in GMP certified facilities.


  • Not effective for some users
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5. BulkSupplements Pure L-Tryptophan Powder

  • L-Tryptophan: 500 mg (3/8 teaspoon)
  • Size: 100 grams

Best L Tryptophan Supplements

BulkSupplements is a major nutritional supplement manufacturer that sells its products not only to consumers but also to other manufacturers. It operates from a GMP-certified facility and upholds strict manufacturing and testing process to ensure the quality of the products remain untainted.

L-Tryptophan is proven to be effective in raising your serotonin and melatonin level. However, swallowing capsules may not be everyone’s favorite. This pack of L-Tryptophan powder allows you to mix the amino acids in your favorite juices with the same mood-boosting effect.

The L-Tryptophan powder is packed in a zippable foil pouch to allow easy storage. They are also tested stringently to ensure the powder is pure from harmful contaminants. Take 3/8 tablespoon of the L-Tryptophan powder 3 times a day to promote a healthier mind.


  • Alternative powder form
  • Fast acting L-Tryptophan powder
  • Relaxing for the mind and promotes sleep


  • No positive effects for some individuals.
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6. Nutricost L-Tryptophan Capsules

  • L-Tryptophan: 500 mg ( 1 capsule)
  • Size: 120 Capsules

Best L Tryptophan Supplements

Nutricost supplies a decent range of health supplements from its online store and other online retailers. It places great importance on the potency and purity of its products. You’ll be assured that any Nutricost supplement’s quality is unrivaled and effective.

A single bottle of L-Tryptophan supplement by Nutricost contains 120 capsules. Each of the capsules has 500 mg of L-Tryptophan. To increase your serotonin and melatonin to a healthy level, it is recommended that you take a single capsule 2-3 times a day on an empty stomach.

This high quality L-Tryptophan capsules will help you relax and alleviate any stress that you may suffer along the day. They are tested to ensure no harmful chemicals made its way into the highly potent capsules.


  • Non-GMO, Gluten-free
  • Helps with sleep
  • Promote relaxation


  • Not efficient for some people
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7. Doctor’s Best L-Tryptophan

  • L-Tryptophan: 500 mg ( 1 capsule)
  • Size: 90 Capsules

Best L Tryptophan Supplements

As the name implies, Doctor’s Best was founded in 1990, by experienced physicians, to offer nutritional supplements to the public. The products are made from high-quality ingredients and scientifically tested to ensure they are effective and safe.

This is another L-Tryptophan capsules that suit vegetarians. Taking 2-3 capsules a day will help to alleviate stress. The capsules have undergone 3rd party testing after being produced in a GMP certified facility. This means that the capsules are free from harmful fillers.

If you’ve been struggling with sleepless nights, taking these L-Tryptophan will also end your ordeal. It boosts melatonin, a naturally produced hormone that calms your mind and allows it to sleep easily. To ensure the L-Tryptophan is absorbed efficiently, it is recommended that you do not take the capsules with other protein-rich food.


  • Tested for purity according to JP and USP standards.
  • Helps to calm the anxious mind
  • Promote deeper sleep


  • Not effective for some consumers.
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8. Lidtke Technologies L-Tryptophan Capsules

  • L-Tryptophan: 500 mg ( 1 capsule)
  • Size: 120 Capsules

Best L Tryptophan Supplements

The team at Lidtke Technologies are determined to make the planet a better place while it strives to produce the best nutritional supplements for the public. It takes great pain in sourcing the finest material and ensures that no organic or inorganic contaminants are present in their products.

The L-Tryptophan capsules by Lidtke Technologies offer a natural way to alleviate your stress. It boosts the serotonin level in your brain and ensures the neuron function optimally. Taking a single capsule a day will ensure you get the required boost in your mood.

Vegan who are dealing with stress will find the vegetarian capsules perfect. The supplement also Non-GMO. You’ll experience the pure benefit of L-Tryptophan minus harmful additives. It is also suggested that supplementing with L-Tryptophan may reduce your craving for carbohydrates.


  • Non-GMO, vegetarian capsules.
  •  Reduce food craving.
  • Calms the mind and made sleep easier.


  • Some individuals experience side effects.
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9. Pure Naturals L-Tryptophan Dietary Supplement

  • L-Tryptophan: 500 mg ( 1 capsule)
  • Size: 120 Capsules

Best L Tryptophan Supplements

Pure Naturals is a relative newcomer into the nutritional supplement industry. Founded in 2014, it has been consistently producing high-quality wellness products in a GMP certified facility. Offering great value with their supplements, Pure Naturals has grown considerably in the past 3 years.

Each of the capsules contains 500 mg of L-Tryptophan, important amino acids that regulate mental health and sleep cycle in humans. The capsules are manufactured in a GMP certified facility in the US. You can be assured that there are no herbs or drugs that compromise the purity of the amino acids.

L-Tryptophan can help you to alleviate stress when you take a single capsule 2-3 times daily. Taking the supplement before bedtime also helps you to sleep better and deeper.


  • Manufactured in GMP certified facility
  • Potent L-Tryptophan for sleep disorders.
  • Helps alleviate stress.


  • May not work for some individuals.
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10. BRI Nutrition L-Tryptophan Capsules

  • L-Tryptophan: 1500 mg ( 3 capsules)
  • Size: 120 Capsules

Best L Tryptophan Supplements

BRI nutrition is clear of its mission to provide high-quality nutritional products that meet the demand of modern and challenging lifestyle. It does so by harvesting only the finest ingredients and implement a strict manufacturing process in its GMP certified facility.

The lack of L-Tryptophan can produce a series of disorders. Anxiety and insomnia are commonly reported. Taking a single capsule of BRI Nutrition L-tryptophan helps to replenish the essential amino acid. As the serotonin and melatonin level are back to normal, you’ll feel calmer and sleep is no longer a dreaded experience.

The capsules are tested for quality assurance after they are manufactured in a GMP certified facility. This means that you can expect a highly potent L-Tryptophan supplement that is free for impurities.


  • Helps to boost your mood.
  • Allow easier and better sleep.
  • Manufactured in GMP certified facility


  • Little effects for some consumers.
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Important Reminders Before You Start Taking L-Tryptophan Supplements

As effective as it is, it pays to be extra-cautions when taking L-Tryptophan. Here are a few kind reminders before you start introducing L-tryptophan as a supplement.

  • If you’re unsure of the right dosage, always check with your physicians.
  • Stop taking L-Tryptophan if you’re experiencing side effects. Consult with your doctor for further advice.
  • Remember to read the instructions on the manufacturer labels before taking the supplements.

I hope this guide has helped you in choosing the right L-Tryptophan for your stress and sleep issues. Share any of your experience with L-Tryptophan in the comment below.


Kenny Lee

I am an engineer-turned-writer who once struggle with social anxiety. After overcoming problems inflicted by low self-esteem and the fear of interaction, I realize the need for taking a holistic approach in developing our mind. I'm sharing my experience, remedies, and techniques that interest me in my quest to be a better self.

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